| Primary Identifier | MGI:88157 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 12097 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables hormone activity and hydroxyapatite binding activity. A structural constituent of bone. Involved in several processes, including negative regulation of bone development; regulation of testosterone biosynthetic process; and type B pancreatic cell proliferation. Acts upstream of or within cellular lipid catabolic process; pancreas development; and positive regulation of insulin secretion. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including bone; forelimb; jaw; rib; and tongue. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein). PHENOTYPE: Mice homozygous for a knock-out allele of both Bglap1 and Bglap2 exhibit decreased circulating insulin, impaired glucose tolerance, increased adipose tissue, increased bone density, and decreased male fertility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
