| First Author | Cariappa A | Year | 2009 |
| Journal | J Exp Med | Volume | 206 |
| Issue | 1 | Pages | 125-38 |
| PubMed ID | 19103880 | Mgi Jnum | J:144035 |
| Mgi Id | MGI:3829814 | Doi | 10.1084/jem.20081399 |
| Citation | Cariappa A, et al. (2009) B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. J Exp Med 206(1):125-38 |
| abstractText | We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of alpha2-6-linked sialic acid, exhibit enhanced B cell receptor (BCR) activation, defects in peripheral B cell development, and spontaneously develop antichromatin autoantibodies and glomerular immune complex deposits. The 9-O-acetylation state of sialic acid regulates the function of CD22, a Siglec that functions in vivo as an inhibitor of BCR signaling. These results describe a novel catalytic regulator of B cell signaling and underscore the crucial role of inhibitory signaling in the maintenance of immunological tolerance in the B lineage. |
