| Type | MGI:General | Description | at E9.5, 8 of 22 homozygotes show isolated defects in yolk sac vasculogenesis, with variable severiry; 5 display a combination of both vascular and hematopoietic defects defects range from a delay in vasculogenesis to development of small and disorganized delicate vessels to complete absence of vitelline vessels in severe cases notably, 3 of 5 homozygous embryos conceived by a homozygous mutant mother are still alive at E12.5 but show severely reduced vascular networks in their yolk sacs |
