| Primary Identifier | IPR034968 | Type | Family |
| Short Name | Reelin |
| description | Reelin is an extracellular matrix serine protease that regulates neuronal migration during embryonic development and acts as a modulator of synaptic transmission in the adult brain []. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons [, , ]. In the adult brain, reelin stabilizes the actin cytoskeleton by inducing cofilin phosphorylation. Decreased Reelin expression causes destabilization of neurons, which could have implications for brain disorders, such as epilepsy and schizophrenia []. |
