| Primary Identifier | MGI:3046825 | Allele Type | Targeted |
| Gene | Polg | Transmission | Germline |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Polgtm1Lrsn mice were mated with ubiquitously expressing Flp-mice to excise the Frt-flanked neo, leaving exon 3 flanked with loxP sites and an aspartic acid to alanine codon change at 257, in the second exonuclease domain. Biochemical assays revealed a profound reduction in exonuclease activity in these mutants. |
