| First Author | Mostert V | Year | 2000 |
| Journal | Arch Biochem Biophys | Volume | 376 |
| Issue | 2 | Pages | 433-8 |
| PubMed ID | 10775431 | Mgi Jnum | J:61582 |
| Mgi Id | MGI:1355188 | Doi | 10.1006/abbi.2000.1735 |
| Citation | Mostert V (2000) Selenoprotein P: properties, functions, and regulation. Arch Biochem Biophys 376(2):433-8 |
| abstractText | Selenoprotein P (SeP) is a plasma protein which contains 10 selenocysteine residues per polypeptide. It accounts for more than 50% of the selenium content in rat and human plasma but its function is still not completely understood. However, a function as an extracellular antioxidant seems most probable. A protective function of SeP in human plasma against the potent endotoxin peroxynitrite and phospholipid hydroperoxide reducing activity was demonstrated in vitro. An association of SeP with the vascular endothelium, a prime target of peroxynitrite toxicity, was shown in vivo. SeP of bovine serum acts as a survival-promoting factor in neuronal cell culture. Analysis of the human SeP promoter indicates a transcriptional regulation of SeP by inflammatory mediators. Copyright 2000 Academic Press. |
