| Primary Identifier | MGI:1916214 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 68964 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables single-stranded DNA binding activity. Involved in positive regulation of DNA replication. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; hematopoietic stem cell proliferation; and replicative senescence. Located in chromosome, telomeric region and nucleus. Part of CST complex. Is expressed in genitourinary system. Orthologous to human CTC1 (CST telomere replication complex component 1). PHENOTYPE: Mice homozygous for a targeted allele exhibit defective telomere replication that leads to stem cell exhaustion, bone marrow failure and premature death. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
