Primary Identifier | MGI:2443957 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 329003 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA-binding transcription factor binding activity and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including adipose tissue development; brown fat cell differentiation; and positive regulation of cold-induced thermogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ZNF516 (zinc finger protein 516). PHENOTYPE: Mice homozygous for a null allele die immediately after birth and show decreased white adipose tissue cell size, and abnormal presumptive brown adipose tissue morphology with abnormal mitochondria at E20.5. [provided by MGI curators] |