| Primary Identifier | MGI:2444576 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 240641 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including positive regulation of mitotic cytokinetic process; positive regulation of neuron migration; and protein localization to microtubule. Acts upstream of or within neural tube closure; regulation of establishment of protein localization; and regulation of neuron migration. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and spindle midzone. Is expressed in cerebral cortex marginal layer; cerebral cortex ventricular layer; cortical plate; and cortical subplate. Used to study microcephaly. Orthologous to human KIF20B (kinesin family member 20B). PHENOTYPE: Mice homozygous for ENU induced mutations display craniofacial and nervous system abnormalities including exencephaly, microcephaly, decreased forebrain size and impaired neuronal progenitor proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
