| First Author | Lin RH | Year | 1994 |
| Journal | Scand J Immunol | Volume | 39 |
| Issue | 5 | Pages | 446-52 |
| PubMed ID | 8191220 | Mgi Jnum | J:18411 |
| Mgi Id | MGI:66695 | Doi | 10.1111/j.1365-3083.1994.tb03399.x |
| Citation | Lin RH, et al. (1994) The treatment of autoimmune disease in (NZB/NZW)F1 mice with syngeneic photomodulated splenocytes. Scand J Immunol 39(5):446-52 |
| abstractText | (NZB x NZW)F1 (B/W) mice spontaneously develop a disease which is remarkably similar to systemic lupus erythematosus (SLE) in humans. This disease is characterized by the appearance of autoantibodies to double-stranded (ds)DNA and the subsequent development of fatal glomerulonephritis. The prophylactic treatment of B/W mice with syngeneic photomodulated autoimmune spleen cells was found to significantly improve survival, and to inhibit the outgrowth of autoreactive B cells and the production of high-titre IgG anti-dsDNA antibodies. The function of the autoreactive T cells in vivo, however, did not change significantly. Our findings suggested a novel treatment for spontaneously occurring autoantibody-related autoimmune diseases. |
