Primary Identifier | MGI:1916813 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 69563 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables enzyme inhibitor activity. Acts upstream of or within negative regulation of calcium ion import into sarcoplasmic reticulum and response to wounding. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including diaphragm; heart; leg muscle; somite; and tongue. Orthologous to human MRLN (myoregulin). PHENOTYPE: Mice homozygous for a knock-out allele show improved exercise performance and enhanced Ca2+ handling in skeletal muscle. Mice homozygous for another knock-out exhibit reduced myofiber numbers and muscle regeneration. [provided by MGI curators] |