Primary Identifier | MGI:1931527 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 50709 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables DNA binding activity. A structural constituent of chromatin. Acts upstream of or within chromatin organization and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in early conceptus and oocyte. Orthologous to human H1-4 (H1.4 linker histone, cluster member). PHENOTYPE: Homozygotes for targeted null mutations are normal, but Hist1h1e/Hist1h1c double knockout males are significantly smaller than normal. The Hist1h1e/Hist1h1d/Hist1h1e triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented. [provided by MGI curators] |