| Primary Identifier | MGI:1340044 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 16975 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including amyloid-beta binding activity; apolipoprotein binding activity; and reelin receptor activity. Involved in several processes, including nervous system development; reelin-mediated signaling pathway; and regulation of dendrite development. Acts upstream of or within hippocampus development and layer formation in cerebral cortex. Located in cell surface and extracellular space. Is expressed in nervous system and retina layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). PHENOTYPE: Homozygotes for a targeted null mutation exhibit impaired granule cell migration, radial glial scaffold formation, contextual fear conditioning, and long-term potentiation. Mutant males have abnormal sperm and are sterile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
