| First Author | Gao WQ | Year | 1993 |
| Journal | Science | Volume | 260 |
| Issue | 5106 | Pages | 367-9 |
| PubMed ID | 8469990 | Mgi Jnum | J:127691 |
| Mgi Id | MGI:3764613 | Doi | 10.1126/science.8469990 |
| Citation | Gao WQ, et al. (1993) Neuronal differentiation rescued by implantation of Weaver granule cell precursors into wild-type cerebellar cortex. Science 260(5106):367-9 |
| abstractText | The migration of postmitotic neurons away from compact, germinal zones is a critical step in neuronal differentiation in the developing brain. To study the molecular signals necessary for cerebellar granule cell migration in situ, precursor cells from the neurological mutant mouse weaver, an animal with phenotypic defects in migration, were implanted into the external germinal layer (EGL) of wild-type cerebellar cortex. In this region, labeled weaver precursor cells of the EGL progressed through all stages of granule neuron differentiation, including the extension of parallel fibers, migration through the molecular and Purkinje cell layers, positioning in the internal granule cell layer, and extension of dendrites. Thus, the weaver gene acts nonautonomously in vivo, and local cell interactions may induce early steps in neuronal differentiation that are required for granule cell migration. |
