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Allele : Trp53<tm3Glo> transformation related protein 53; targeted mutation 3, Guillermina Lozano
Primary Identifier  MGI:3722177 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Trp53
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<+>
Is Recombinase  false Is Wild Type  false
molecularNote  An arginine to histidine substitution was generated at codon 172 (p.R172H, equivalent to p.R175H in humans) by insertion of a targeting construct containing a loxP site flanked neomycin resistance gene cassette and an G-to-A mutation at coding nucleotide 515. Retention of the floxed selection cassette results in inactivation.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Neo-p53<R172H>,
  • Neo-p53<R172H>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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9 Publication categories

Trail: Allele




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