| Type | MGI:General | Description | at 4 weeks of age, homozygotes are impaired in their urine-concentrating ability relative to wild-type controls the urine osmolality of euhydrated mutant mice is about one-third of that in wild-type mice after either injection of the V2R agonist dDAVP or water deprivation, homozygotes display only a ~28% increase in urine osmilarity vs a 85% increase in similarly-treated wild-type mice |