| Primary Identifier | IPR032868 | Type | Family |
| Short Name | FTO |
| description | Nine mammalian AlkB homologues exist, ALKBH1-8 and FTO [, ]. FTO, also known as Fat mass and obesity-associated protein, is an alpha-ketoglutarate-dependent dioxygenase involved in alkylated DNA and RNA repair []. FTO activity is highest towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine []. It has no detectable activity towards double-stranded DNA. FTO requires molecular oxygen, alpha-ketoglutarate and iron. FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis, as well as the regulation of body size and body fat accumulation []. |
