| First Author | Andrae J | Year | 2016 |
| Journal | Biol Open | Volume | 5 |
| Issue | 4 | Pages | 461-74 |
| PubMed ID | 26988758 | Mgi Jnum | J:232500 |
| Mgi Id | MGI:5779455 | Doi | 10.1242/bio.017368 |
| Citation | Andrae J, et al. (2016) A role for PDGF-C/PDGFRalpha signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex. Biol Open 5(4):461-74 |
| abstractText | Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRalpha. Analysis ofPdgfcnull mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy with other PDGFRalpha ligands might obscure additional functions. In search of further developmental roles for PDGF-C, we generated mice that were double mutants forPdgfc(-/-)andPdgfra(GFP/+) These mice display a range of severe phenotypes including spina bifida, lung emphysema, abnormal meninges and neuronal over-migration in the cerebral cortex. We focused our analysis on the central nervous system (CNS), where PDGF-C was identified as a critical factor for the formation of meninges and assembly of the glia limitans basement membrane. We also present expression data onPdgfa,PdgfcandPdgfrain the cerebral cortex and microarray data on cerebral meninges. |
