| First Author | Suenaga T | Year | 2007 |
| Journal | Eur J Immunol | Volume | 37 |
| Issue | 11 | Pages | 3197-207 |
| PubMed ID | 17948262 | Mgi Jnum | J:126332 |
| Mgi Id | MGI:3761042 | Doi | 10.1002/eji.200737052 |
| Citation | Suenaga T, et al. (2007) Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function. Eur J Immunol 37(11):3197-207 |
| abstractText | Lymphocyte proliferation is regulated by signals through antigen receptors, co-stimulatory receptors, and other positive and negative modulators. Several membrane tetraspanning molecules are also involved in the regulation of lymphocyte growth and death. We cloned a new B cell-specific tetraspanning (BTS) membrane molecule, which is similar to CD20 in terms of expression, structure and function. BTS is specifically expressed in the B cell line and its expression is increased after the pre-B cell stage. BTS is expressed in intracellular granules and on the cell surface. Overexpression of BTS in immature B cell lines induces growth retardation through inhibition of cell cycle progression and cell size increase without inducing apoptosis. This inhibitory function is mediated predominantly by the N terminus of BTS. The development of mature B cells is inhibited in transgenic mice expressing BTS, suggesting that BTS is involved in the in vivo regulation of B cells. These results indicate that BTS plays a role in the regulation of cell division and B cell growth. |
