| First Author | Sakai D | Year | 2022 |
| Journal | Mol Brain | Volume | 15 |
| Issue | 1 | Pages | 28 |
| PubMed ID | 35361248 | Mgi Jnum | J:323013 |
| Mgi Id | MGI:7260855 | Doi | 10.1186/s13041-022-00911-0 |
| Citation | Sakai D, et al. (2022) Hif1alpha-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model. Mol Brain 15(1):28 |
| abstractText | Hypoxia-inducible factor 1 alpha (Hif1alpha) plays a crucial role in brain development. To study the function of Hif1alpha in early brain development, we generated neuroepithelial cell-specific Hif1alpha-knockout mice. Hif1alpha-knockout mice died soon after birth; these mice exhibited an abnormal head shape, indicating the presence of brain defects. Morphological analysis revealed that Hif1alpha ablation reduced the overall size of the brain, especially affecting the telencephalon. Neuronal apoptosis predominantly occurred in deep-layer neurons, consequently the alignment of cortical layers was severely disorganized in Hif1alpha knockout mice. Furthermore, we demonstrated that Vegf signaling contributes to the survival of deep-layer neurons as a downstream effector of Hif1alpha-dependent hypoxia signaling. Taken together, our findings demonstrate that Hif1alpha plays a critical role in the early stages of telencephalon development. |
