| First Author | Heisler LK | Year | 2007 |
| Journal | Genes Brain Behav | Volume | 6 |
| Issue | 5 | Pages | 491-6 |
| PubMed ID | 17451451 | Mgi Jnum | J:137308 |
| Mgi Id | MGI:3798744 | Doi | 10.1111/j.1601-183X.2007.00316.x |
| Citation | Heisler LK, et al. (2007) Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes Brain Behav 6(5):491-6 |
| abstractText | Central serotonin (5-hydroxytryptamine, 5-HT) systems have been implicated in the pathophysiology and treatment of anxiety disorders, which are among the world's most prevalent psychiatric conditions. Here, we report that the 5-HT(2C) receptor (5-HT(2C)R) subtype is critically involved in regulating behaviors characteristic of anxiety using male 5-HT(2C)R knockout (KO) mice. Specific neural substrates underlying the 5-HT(2C)R KO anxiolytic phenotype were investigated, and we report that 5-HT(2C)R KO mice display a selective blunting of extended amygdala corticotropin-releasing hormone neuronal activation in response to anxiety stimuli. These findings illustrate a mechanism through which 5-HT(2C)Rs affect anxiety-related behavior and provide insight into the neural circuitry mediating the complex psychological process of anxiety. |
