| First Author | Liu Z | Year | 2017 |
| Journal | Biochem Biophys Res Commun | Volume | 490 |
| Issue | 1 | Pages | 62-68 |
| PubMed ID | 28600172 | Mgi Jnum | J:251235 |
| Mgi Id | MGI:6103469 | Doi | 10.1016/j.bbrc.2017.06.012 |
| Citation | Liu Z, et al. (2017) Conditional knockout of microRNA-31 promotes the development of colitis associated cancer. Biochem Biophys Res Commun 490(1):62-68 |
| abstractText | MicroRNA-31 (miR-31) is an evolutionarily conserved microRNA, and its biological function in colorectal cancer and other cancers is controversial. In this study, we identified the host gene of mouse miR-31 and found that miR-31 was over-expressed in both human colorectal cancer and mouse colon cancer models. We here developed a miR-31 conditional knockout mouse model that allows for colon epithelium specific deletion of miR-31 to investigate its functionality in colon cancer development. We demonstrated that mice with miR-31 conditional deletion resulted in more severe colitis-associated cancer than wild-type, and we further identified Wdr5 as an important target of miR-31. |
