| First Author | Djabali M | Year | 1992 |
| Journal | Nat Genet | Volume | 2 |
| Issue | 2 | Pages | 113-8 |
| PubMed ID | 1303259 | Mgi Jnum | J:34111 |
| Mgi Id | MGI:81585 | Doi | 10.1038/ng1092-113 |
| Citation | Djabali M, et al. (1992) A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias [published erratum appears in Nat Genet 1993 Aug;4(4):431]. Nat Genet 2(2):113-8 |
| abstractText | Some acute lymphocytic leukaemias, particularly those in young children, are associated with a t(4;11)(q21;q23) reciprocal translocation. We have cloned the translocation breakpoint on chromosome 11q23 and isolated corresponding RNA transcripts from this region. The translocation occurs within a cluster of Alu repetitive elements located within an intron of a gene that gives rise to 11.5 (kb) transcript spanning the translocation breakpoint. The 11.5 kb transcript encodes a protein that is highly homologous to the Drosophila trithorax gene, a developmental regulator. An analysis of a series of leukaemic patients carrying t(4;11) and t(9;11) translocations indicate that the majority of breakpoints in infant leukaemias lie within a 5 kb region. |
