Primary Identifier | MGI:2448895 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Mepe |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The gene was disrupted by replacement of exon 3 with a PGK-neo cassette via homologous recombination, resulting in deletion of amino acids 27-441. Northern blot analysis of tibia RNA from homozygous animals did not detect transcripts. Immunohistochemistry of tibia sections from homozygous mutant mice confirmed the absence of gene product. |