| First Author | Cuppen E | Year | 1999 |
| Journal | FEBS Lett | Volume | 459 |
| Issue | 3 | Pages | 291-8 |
| PubMed ID | 10526152 | Mgi Jnum | J:58365 |
| Mgi Id | MGI:1349753 | Doi | 10.1016/s0014-5793(99)01191-6 |
| Citation | Cuppen E, et al. (1999) Identification and molecular characterization of BP75, a novel bromodomain-containing protein. FEBS Lett 459(3):291-8 |
| abstractText | We here describe the identification and characterization of a novel bromodomain-containing protein, the bromodomain protein of 75 kDa (BP75). Initially, we identified BP75 in a two-hybrid screening for proteins that interact with the first PDZ (acronym for post-synaptic density protein PSD-95, Drosophila discs large tumor suppressor DlgA and the tight junction protein ZO-1) domain in protein tyrosine phosphatase-BAS-like (PTP-BL). We found that BP75 is expressed ubiquitously and show that both BP75 and a PTP-BL deletion mutant consisting of the first PDZ domain are located mainly in the nucleus, although cytoplasmic localization is also evident. Full-length PTP-BL, on the contrary, is predominantly localized in the cytoplasm, although some basal nuclear staining is observed. The described molecular interaction may reflect a mechanism of coupling submembraneous signalling events and nuclear events. |
