| First Author | Bekman E | Year | 2002 |
| Journal | Mech Dev | Volume | 119 Suppl 1 |
| Pages | S77-81 | PubMed ID | 14516664 |
| Mgi Jnum | J:85287 | Mgi Id | MGI:2673755 |
| Doi | 10.1016/s0925-4773(03)00095-9 | Citation | Bekman E, et al. (2002) Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene. Mech Dev 119 Suppl 1:S77-81 |
| abstractText | The Drosophila melanogaster gene prickle-spiny-legs (pk) functions in an intercellular feedback loop that is central to the establishment of planar cell polarity in the eye and epidermis of the fly, by modulating Frizzled-Disheveled signalling. Here we identify three mouse prickle-related genes (dyxin, testin and prickle) and describe their expression pattern during murine embryogenesis (E7.5-E15.5). We report that the three genes are expressed in restricted areas of the developing mouse brain: dyxin in the most ventral region of the neural tube and in some localized regions of the ventricular layer of the mesencephalon and rhombencephalon, prickle in the pons region, ventrolateral part of rhombencephalon and motoneurons in the spinal cord, and testin in differentiating neurons of the spinal cord and retina. At the stages analyzed, the main site of expression of testin is the migrating cranial neural crest, while the expression of dyxin is noticeable in myotomal cells and its derivatives, with prickle expression being reciprocally localized to some sclerotomal derivatives, like bone primordia. prickle is also expressed in the apical ectodermal ridge and the most distal mesenchyme of the forming limb buds. |
