| First Author | Gu H | Year | 1994 |
| Journal | Science | Volume | 265 |
| Issue | 5168 | Pages | 103-6 |
| PubMed ID | 8016642 | Mgi Jnum | J:67942 |
| Mgi Id | MGI:1931719 | Doi | 10.1126/science.8016642 |
| Citation | Gu H, et al. (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265(5168):103-6 |
| abstractText | Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal phenotype. With the use of the bacteriophage-derived, site-specific recombinase Cre in a transgenic approach, the same mutation can be selectively introduced into a particular cellular compartment-in this case, T cells. The impact of the mutation on those cells can then be analyzed because the mutant animals are viable. |
