| Primary Identifier | IPR003519 | Type | Family |
| Short Name | OspF/SpvC |
| description | This entry includes the virulence protein SpvC and the phosphothreonine lyase OspF. OspF catalyses the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of proinflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host [, , ].The spv region of the Salmonella virulence plasmids consists of five genes located on an 8-kb fragment, shown to be essential for virulence in mice []. SpvC (also known as mkfA and VirA []) is part of this gene cluster and is utilised by the microbe upon entry into macrophages, although the exact mechanism is unclear. |
