| First Author | Lyu MS | Year | 1996 |
| Journal | J Virol | Volume | 70 |
| Issue | 2 | Pages | 830-3 |
| PubMed ID | 8551621 | Mgi Jnum | J:30535 |
| Mgi Id | MGI:78042 | Doi | 10.1128/jvi.70.2.830-833.1996 |
| Citation | Lyu MS, et al. (1996) Genetic basis for resistance to polytropic murine leukemia viruses in the wild mouse species Mus castaneus. J Virol 70(2):830-3 |
| abstractText | Cultured cells derived from the wild mouse species Mus castaneus were found to be uniquely resistant to exogenous infection by polytropic mink cell focus-forming (MCF) murine leukemia viruses (MuLVs). This MCF MuLV resistance is inherited as a genetically recessive trait in the progeny of F1 crosses between M. castaneus and MCF MuLV-susceptible laboratory mice. Examination of the progeny of backcrosses demonstrated that susceptibility is inherited as a single gene which maps to chromosome 1. The map location of this gene places it at or near the locus Rmc1, the gene encoding the receptor for MCF/xenotropic MuLVs, suggesting that resistance is mediated by the M. castaneus allele of this receptor. |
