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Protein Coding Gene : Rnf41 ring finger protein 41

Primary Identifier  MGI:1914838 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  67588
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables erythropoietin receptor binding activity and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including negative regulation of mitophagy; protein polyubiquitination; and regulation of hemopoiesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum tubular network. Is expressed in several structures, including central nervous system; dorsal root ganglion; male reproductive system; and urinary system. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41).
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit male infertility. In contrast, mice homozygous for a gene trapped allele showed no overt phenotypes but show an increase in activation of naive CD8+ T cells before TCR engagement. [provided by MGI curators]
  • synonyms:
  • Nrdp1,
  • ring finger protein 41,
  • D10Ertd722e,
  • Rnf41,
  • MGI:1289336,
  • FLRF,
  • RIKEN cDNA 4930511A05 gene,
  • MGI:1918379,
  • RIKEN cDNA 2210404G21 gene,
  • RIKEN cDNA 4933415P08 gene,
  • 4933415P08Rik,
  • 2210404G21Rik,
  • MGI:1922926,
  • 4930511A05Rik,
  • DNA segment, Chr 10, ERATO Doi 722, expressed

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