Type | MGI:General | Description | at P21, mutants display a >2-fold increase in epithelial cell proliferation in the eyelids, cornea, and conjunctiva, as determined by Ki67 staining Ki67-positive cells are significantly increased in mutant palpebral epidermis and eyelid hair follicles while Ki67-positive cells are restricted to basal epithelia in wild-type controls, they are also found in the spinous cell layers in the mutant cornea and conjunctiva |