| First Author | Garceau N | Year | 2000 |
| Journal | J Exp Med | Volume | 191 |
| Issue | 2 | Pages | 381-6 |
| PubMed ID | 10637282 | Mgi Jnum | J:112437 |
| Mgi Id | MGI:3656335 | Doi | 10.1084/jem.191.2.381 |
| Citation | Garceau N, et al. (2000) Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40. J Exp Med 191(2):381-6 |
| abstractText | CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-kappaB activation via CD40. |
