| First Author | Sternfeld M | Year | 1998 |
| Journal | J Physiol Paris | Volume | 92 |
| Issue | 3-4 | Pages | 249-55 |
| PubMed ID | 9789818 | Mgi Jnum | J:132121 |
| Mgi Id | MGI:3775156 | Doi | 10.1016/s0928-4257(98)80028-4 |
| Citation | Sternfeld M, et al. (1998) Position effect variegations and brain-specific silencing in transgenic mice overexpressing human acetylcholinesterase variants. J Physiol Paris 92(3-4):249-55 |
| abstractText | Position effect variegations as well as brain-specific silencing were observed in novel transgenic mouse pedigrees expressing human acetylcholinesterase (AChE) variants. Muscle AChE activities varied between 1.6- and 350-fold of control in these lines, one carrying insertion-inactivated InE6-AChE and two with 'readthrough' I4/E5 AChE, all under control of the ubiquitous CMV promoter. In contrast, brain AChE levels remained within a range of 1.5-fold over control, suggesting an upper limit of brain AChE which is compatible with life. |
