| First Author | San Martin S | Year | 2004 |
| Journal | Am J Reprod Immunol | Volume | 52 |
| Issue | 1 | Pages | 53-9 |
| PubMed ID | 15214943 | Mgi Jnum | J:91312 |
| Mgi Id | MGI:3046472 | Doi | 10.1111/j.1600-0897.2004.00182.x |
| Citation | San Martin S, et al. (2004) Perlecan and Syndecan-4 in Uterine Tissues during the Early Pregnancy in Mice. Am J Reprod Immunol 52(1):53-9 |
| abstractText | San Martin S, Soto-Suazo M, Zorn TMT. Perlecan and Syndecan-4 in uterine tissues during the early pregnancy in mice. AJRI 2004; 52:53-59 Copyright Blackwell Munksgaard, 2004Problem: During early pregnancy in mice, there is recruitment of specific immune cells, remodeling of the endometrium, cell differentiation and synthesis of new molecules. Method of study: Immunohistochemistry was used to determine the distribution of perlecan and syndecan-4 in the uteri before and after embryo implantation. Results: During pre-implantation, perlecan was identified in basement membranes and extracellular spaces of the endometrial stroma. In contrast, expression of syndecan-4 was quite weak. In the peri-implantation period, perlecan remained in the basement membranes, and it was no longer observed in the stroma and it was identified in the embryonic cells. On day 4 of pregnancy, syndecan-4 increased in the fibroblasts of the subepithelial stroma. After implantation, syndecan-4 was pronounced in pre-decidual and mature decidual cells. Conclusions: The coordinate balance between the pre- and post-implantation periods suggests a role of these two molecules in the adaptive modification of the uterine microenvironment to receive and implant the embryo. |
