| First Author | Rybkin II | Year | 2007 |
| Journal | J Cell Biol | Volume | 179 |
| Issue | 3 | Pages | 527-37 |
| PubMed ID | 17984325 | Mgi Jnum | J:187574 |
| Mgi Id | MGI:5437436 | Doi | 10.1083/jcb.200707101 |
| Citation | Rybkin II, et al. (2007) Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. J Cell Biol 179(3):527-37 |
| abstractText | Atrial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins, named RRP17, which is expressed specifically in cardiomyocytes, neurons, and the pancreas. RRP17 interacts with Ca(2+)-activated protein for secretion-1 (CAPS1), one of only a few proteins known to be associated exclusively with LDCV exocytosis. Ectopic expression of RRP17 in cardiomyocytes enhances secretion of atrial natriuretic peptide (ANP), a regulator of blood pressure and natriuresis. Conversely, genetic deletion of RRP17 in mice results in dysmorphic LDCVs, impaired ANP secretion, and hypertension. These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues. |
