First Author | Feng X | Year | 2014 |
Journal | PLoS One | Volume | 9 |
Issue | 6 | Pages | e100783 |
PubMed ID | 24949727 | Mgi Jnum | J:218856 |
Mgi Id | MGI:5618589 | Doi | 10.1371/journal.pone.0100783 |
Citation | Feng X, et al. (2014) PTPRT regulates high-fat diet-induced obesity and insulin resistance. PLoS One 9(6):e100783 |
abstractText | Obesity is a risk factor for many human diseases. However, the underlying molecular causes of obesity are not well understood. Here, we report that protein tyrosine phosphatase receptor T (PTPRT) knockout mice are resistant to high-fat diet-induced obesity. Those mice avoid many deleterious side effects of high-fat diet-induced obesity, displaying improved peripheral insulin sensitivity, lower blood glucose and insulin levels. Compared to wild type littermates, PTPRT knockout mice show reduced food intake. Consistently, STAT3 phosphorylation is up-regulated in the hypothalamus of PTPRT knockout mice. These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity. |