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Publication : PTPRT regulates high-fat diet-induced obesity and insulin resistance.

First Author  Feng X Year  2014
Journal  PLoS One Volume  9
Issue  6 Pages  e100783
PubMed ID  24949727 Mgi Jnum  J:218856
Mgi Id  MGI:5618589 Doi  10.1371/journal.pone.0100783
Citation  Feng X, et al. (2014) PTPRT regulates high-fat diet-induced obesity and insulin resistance. PLoS One 9(6):e100783
abstractText  Obesity is a risk factor for many human diseases. However, the underlying molecular causes of obesity are not well understood. Here, we report that protein tyrosine phosphatase receptor T (PTPRT) knockout mice are resistant to high-fat diet-induced obesity. Those mice avoid many deleterious side effects of high-fat diet-induced obesity, displaying improved peripheral insulin sensitivity, lower blood glucose and insulin levels. Compared to wild type littermates, PTPRT knockout mice show reduced food intake. Consistently, STAT3 phosphorylation is up-regulated in the hypothalamus of PTPRT knockout mice. These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity.
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