| First Author | Liu P | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 6 | Pages | 525-32 |
| PubMed ID | 12717432 | Mgi Jnum | J:83646 |
| Mgi Id | MGI:2662805 | Doi | 10.1038/ni925 |
| Citation | Liu P, et al. (2003) Bcl11a is essential for normal lymphoid development. Nat Immunol 4(6):525-32 |
| abstractText | Bcl11a (also called Evi9) functions as a myeloid or B cell proto-oncogene in mice and humans, respectively. Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis. Bcl11a mutant embryos lack B cells and have alterations in several types of T cells. Phenotypic and expression studies show that Bcl11a functions upstream of the transcription factors Ebf1 and Pax5 in the B cell pathway. Transplantation studies show that these defects in Bcl11a mutant mice are intrinsic to fetal liver precursor cells. Mice transplanted with Bcl11a-deficient cells died from T cell leukemia derived from the host. Thus, Bcl11a may also function as a non-autonomous T cell tumor suppressor gene. |
