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Publication : PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

First Author  Finck BN Year  2006
Journal  J Clin Invest Volume  116
Issue  3 Pages  615-22
PubMed ID  16511594 Mgi Jnum  J:106493
Mgi Id  MGI:3618660 Doi  10.1172/JCI27794
Citation  Finck BN, et al. (2006) PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 116(3):615-22
abstractText  Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
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