| First Author | Parsa R | Year | 2022 |
| Journal | Immunity | Volume | 55 |
| Issue | 7 | Pages | 1234-1249.e6 |
| PubMed ID | 35617965 | Mgi Jnum | J:347567 |
| Mgi Id | MGI:7327005 | Doi | 10.1016/j.immuni.2022.05.001 |
| Citation | Parsa R, et al. (2022) Newly recruited intraepithelial Ly6A(+)CCR9(+)CD4(+) T cells protect against enteric viral infection. Immunity 55(7):1234-1249.e6 |
| abstractText | The intestinal epithelium comprises the body's largest surface exposed to viruses. Additionally, the gut epithelium hosts a large population of intraepithelial T lymphocytes, or IELs, although their role in resistance against viral infections remains elusive. By fate-mapping T cells recruited to the murine intestine, we observed an accumulation of newly recruited CD4(+) T cells after infection with murine norovirus CR6 and adenovirus type-2 (AdV), but not reovirus. CR6- and AdV-recruited intraepithelial CD4(+) T cells co-expressed Ly6A and chemokine receptor CCR9, exhibited T helper 1 and cytotoxic profiles, and conferred protection against AdV in vivo and in an organoid model in an IFN-gamma-dependent manner. Ablation of the T cell receptor (TCR) or the transcription factor ThPOK in CD4(+) T cells prior to AdV infection prevented viral control, while TCR ablation during infection did not impact viral clearance. These results uncover a protective role for intraepithelial Ly6A(+)CCR9(+)CD4(+) T cells against enteric adenovirus. |
