| First Author | Arakawa H | Year | 1993 |
| Journal | J Biol Chem | Volume | 268 |
| Issue | 7 | Pages | 4651-5 |
| PubMed ID | 8444838 | Mgi Jnum | J:4343 |
| Mgi Id | MGI:52838 | Doi | 10.1016/s0021-9258(18)53445-1 |
| Citation | Arakawa H, et al. (1993) The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints. J Biol Chem 268(7):4651-5 |
| abstractText | A 7255-base pair (bp) sequence, including the previously sequenced murine segments of I alpha, S alpha, and C alpha, has been completed. Homology matrix comparison revealed a switch repetitive region of 4.2 kilobases (kb) composed of 20-80-bp homology runs, including the previously assigned S alpha region. We distinguished several stretches of duplication, i.e. the central 0.8-kb repetitive region, with some 80-bp staggered consensus repeats containing 20-30-bp subsets, made up of the primordial pentamers CTG(A/G)G. All the break-points of the S alpha switch recombination, including those generated by the translocation of the c-myc protooncogene and those catalyzed by bacterial extracts, are located within the consensus sequence subsets of the 4.2-kb repetitive region. |
