| First Author | Vandrey B | Year | 2020 |
| Journal | Curr Biol | Volume | 30 |
| Issue | 1 | Pages | 169-175.e5 |
| PubMed ID | 31839450 | Mgi Jnum | J:284859 |
| Mgi Id | MGI:6391787 | Doi | 10.1016/j.cub.2019.11.027 |
| Citation | Vandrey B, et al. (2020) Fan Cells in Layer 2 of the Lateral Entorhinal Cortex Are Critical for Episodic-like Memory. Curr Biol 30(1):169-175.e5 |
| abstractText | Episodic memory requires different types of information to be bound together to generate representations of experiences. The lateral entorhinal cortex (LEC) and hippocampus are required for episodic-like memory in rodents [1, 2]. The LEC is critical for integrating spatial and contextual information about objects [2-6]. Further, LEC neurons encode objects in the environment and the locations where objects were previously experienced and generate representations of time during the encoding and retrieval of episodes [7-12]. However, it remains unclear how specific populations of cells within the LEC contribute to the integration of episodic memory components. Layer 2 (L2) of LEC manifests early pathology in Alzheimer's disease (AD) and related animal models [13-16]. Projections to the hippocampus from L2 of LEC arise from fan cells in a superficial sub-layer (L2a) that are immunoreactive for reelin and project to the dentate gyrus [17, 18]. Here, we establish an approach for selectively targeting fan cells using Sim1:Cre mice. Whereas complete lesions of the LEC were previously found to abolish associative recognition memory [2, 3], we report that, after selective suppression of synaptic output from fan cells, mice can discriminate novel object-context configurations but are impaired in recognition of novel object-place-context associations. Our results suggest that memory functions are segregated between distinct LEC networks. |
