| First Author | Chen L | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 19 | Pages | 2843-9 |
| PubMed ID | 18634786 | Mgi Jnum | J:138326 |
| Mgi Id | MGI:3804789 | Doi | 10.1016/j.febslet.2008.07.014 |
| Citation | Chen L, et al. (2008) Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6. FEBS Lett 582(19):2843-9 |
| abstractText | TRAF6 is an E3 ubiquitin ligase that transduces signals from members of the TLR/IL-1R family. Multiple molecules have been found to associate with TRAF6 and exert their functions in this pathway. Herein, by yeast two-hybrid screen using TRAF6 as bait, we identified PP4 as a potential TRAF6-interacting protein. PP4 physically interacted with TRAF6 and was recruited to TLR4 complex upon LPS stimulation. PP4 negatively regulated LPS-induced and TRAF6-mediated NF-kappaB activation by inhibiting the ubiquitination of TRAF6. LPS stimulation also induced the expression of PP4. Taken together, our findings suggest that PP4 is a negative feedback regulator of LPS/TLR4 pathway. |
