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Comment :

Type  disruption phenotype Description  Mice are viable and fertile, but lack behavorial and physiological responses to capsaicin and show impaired responses to noxious heat stimuli. Their dorsal root ganglion neurons do not display calcium channel activation in response to capsaicin or resiniferatoxin. Likewise, their dorsal root ganglion neurons do not display calcium channel activitation in response to low extracellular pH.