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Protein Coding Gene : Ep300 E1A binding protein p300

Primary Identifier  MGI:1276116 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  328572
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables several functions, including N-acyltransferase activity; nucleic acid binding activity; and p53 binding activity. Involved in several processes, including face morphogenesis; protein stabilization; and swimming. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and somitogenesis. Part of histone acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including alimentary system; eye; heart; nervous system; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (E1A binding protein p300).
PHENOTYPE: Homozygotes for a targeted null mutation exhibit defects of the heart, lung, and small intestine and die at midgestation; heterozygotes also show some embryonic loss. Heterozygotes for an acetyltransferase-negative mutation die by the neonatal period. [provided by MGI curators]
  • synonyms:
  • Ep300,
  • KAT3B,
  • E1A binding protein p300,
  • p300

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

62 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For