| First Author | Hyman RW | Year | 1994 |
| Journal | Biochem Genet | Volume | 32 |
| Issue | 11-12 | Pages | 397-407 |
| PubMed ID | 7748156 | Mgi Jnum | J:22990 |
| Mgi Id | MGI:70858 | Doi | 10.1007/BF00566060 |
| Citation | Hyman RW, et al. (1994) Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice. Biochem Genet 32(11-12):397-407 |
| abstractText | Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (apo A-II). QTL analysis revealed a significant locus on chromosome 1 distal impacting serum apo A-II concentration on a high-fat diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumably Apoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus. |
