| Primary Identifier | MGI:893580 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 19152 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including mature conventional dendritic cell differentiation; membrane protein ectodomain proteolysis; and neutrophil extravasation. Predicted to act upstream of or within collagen catabolic process. Predicted to be located in azurophil granule lumen; cytosol; and plasma membrane raft. Predicted to be active in extracellular space. Predicted to colocalize with plasma membrane. Is expressed in early conceptus and liver. Orthologous to human PRTN3 (proteinase 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit delayed neutrophil death and increased neutrophil accumulation at sites of inflammation in a murine model of peritonitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
