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Protein Coding Gene : Dusp3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
Primary Identifier  MGI:1919599 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  72349
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables protein tyrosine/serine/threonine phosphatase activity. Involved in cellular response to epidermal growth factor stimulus; negative regulation of epidermal growth factor receptor signaling pathway; and regulation of focal adhesion assembly. Predicted to be located in immunological synapse and nucleoplasm. Predicted to be active in cytosol. Is expressed in central nervous system; dorsal root ganglion; retina; and urinary system. Orthologous to human DUSP3 (dual specificity phosphatase 3).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased hemoglobin content and angiogenesis in Matrigel plugs and aortic explants. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 5031436O03 gene,
  • VHR,
  • Dusp3,
  • dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related),
  • 2210015O03Rik,
  • MGI:1923216,
  • 5031436O03Rik,
  • RIKEN cDNA 2210015O03 gene,
  • T-DSP11
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