| Primary Identifier | MGI:107420 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 16179 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in several processes, including interleukin-1-mediated signaling pathway; negative regulation of DNA-templated transcription; and negative regulation of cholesterol efflux. Acts upstream of or within cell surface receptor signaling pathway and response to peptidoglycan. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. Cytokine production and response to endotoxin are attenuated however. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
