First Author | Zhang ZH | Year | 2017 |
Journal | Cell Mol Neurobiol | Volume | 37 |
Issue | 7 | Pages | 1303-1310 |
PubMed ID | 28132130 | Mgi Jnum | J:263149 |
Mgi Id | MGI:6161916 | Doi | 10.1007/s10571-017-0465-5 |
Citation | Zhang ZH, et al. (2017) Rab10 Disruption Results in Delayed OPC Maturation. Cell Mol Neurobiol 37(7):1303-1310 |
abstractText | Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice provided in vitro and in vivo evidence that Rab10 is involved in OPC maturation and may affect myelination during OPC development. |