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Publication : Rab10 Disruption Results in Delayed OPC Maturation.

First Author  Zhang ZH Year  2017
Journal  Cell Mol Neurobiol Volume  37
Issue  7 Pages  1303-1310
PubMed ID  28132130 Mgi Jnum  J:263149
Mgi Id  MGI:6161916 Doi  10.1007/s10571-017-0465-5
Citation  Zhang ZH, et al. (2017) Rab10 Disruption Results in Delayed OPC Maturation. Cell Mol Neurobiol 37(7):1303-1310
abstractText  Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice provided in vitro and in vivo evidence that Rab10 is involved in OPC maturation and may affect myelination during OPC development.
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