| First Author | Waltenbaugh C | Year | 1994 |
| Journal | Alcohol | Volume | 11 |
| Issue | 1 | Pages | 47-52 |
| PubMed ID | 8142068 | Mgi Jnum | J:28554 |
| Mgi Id | MGI:66452 | Doi | 10.1016/0741-8329(94)90011-6 |
| Citation | Waltenbaugh C, et al. (1994) Phenotype of lymphocytes mediating copolymer-specific humoral immunity in ethanol-consuming C57BL/6 mice. Alcohol 11(1):47-52 |
| abstractText | Little is known about the mechanisms of impaired immune function in alcoholic patients. We have previously shown that ethanol consumption by mice alters copolymer-specific humoral and cellular immune responses. Does ethanol consumption eliminate suppressor T cells, allowing nonresponder mice to make humoral immune responses to poly(Glu50Tyr50) (GT)? Female C57BL/6 mice were fed a nutritionally complete liquid diet containing 35% ethanol-derived calories for up to 33 days. Control mice were fed an isocaloric control liquid diet or remained on a solid diet and water. Mice fed the ethanol-containing diet made GT-specific plaque-forming cell (PFC) responses, whereas mice fed liquid control or solid diets did not. Lymphocytes from ethanol liquid diet-consuming mice helped splenocytes from either solid or liquid control mice to make a GT-specific PFC response. The cells mediating help were nylon wool nonadherent, CD4-bearing T cells. These findings suggest that ethanol does not eliminate copolymer-specific suppressor cells, but instead alters the functional capability of helper T cells for humoral immune responses. |
